8VTP

Structure of FabS1CE-EPR-1, a high affinity antibody for the erythropoeitin receptor

Summary for 8VTP

• Entry DOI: 10.2210/pdb8vtp/pdb
• Related: 8VTR 8VU1 8VU4 8VUA 8VUC
• Descriptor: S1CE VARIANT OF FAB-EPR-1 heavy chain, S1CE VARIANT OF FAB-EPR-1 light chain, 1,2-ETHANEDIOL, ... (9 entities in total)
• Functional Keywords: proliferation, engineered antibody, high-affinity binding, enhanced crystallization, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 48720.24

Authors

Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sidhu, S.S. (deposition date: 2024-01-26, release date: 2024-07-10)

• Primary citation: Bruce, H.A.,Singer, A.U.,Blazer, L.L.,Luu, K.,Ploder, L.,Pavlenco, A.,Kurinov, I.,Adams, J.J.,Sidhu, S.S.; Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones.; Protein Sci., 33:e5081-e5081, 2024; PubMed: 38924648; DOI: 10.1002/pro.5081

Experimental method

X-RAY DIFFRACTION (1.77 Å)