8VTP

Structure of FabS1CE-EPR-1, a high affinity antibody for the erythropoeitin receptor

8VTP の概要

• エントリーDOI: 10.2210/pdb8vtp/pdb
• 関連するPDBエントリー: 8VTR 8VU1 8VU4 8VUA 8VUC
• 分子名称: S1CE VARIANT OF FAB-EPR-1 heavy chain, S1CE VARIANT OF FAB-EPR-1 light chain, 1,2-ETHANEDIOL, ... (9 entities in total)
• 機能のキーワード: proliferation, engineered antibody, high-affinity binding, enhanced crystallization, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48720.24

構造登録者

Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sidhu, S.S. (登録日: 2024-01-26, 公開日: 2024-07-10)

• 主引用文献: Bruce, H.A.,Singer, A.U.,Blazer, L.L.,Luu, K.,Ploder, L.,Pavlenco, A.,Kurinov, I.,Adams, J.J.,Sidhu, S.S.; Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones.; Protein Sci., 33:e5081-e5081, 2024; PubMed: 38924648; DOI: 10.1002/pro.5081

実験手法

X-RAY DIFFRACTION (1.77 Å)