8VPP
Phosphorylated human NCC in complex with chlorthalidone
Summary for 8VPP
Entry DOI | 10.2210/pdb8vpp/pdb |
EMDB information | 43412 |
Descriptor | Solute carrier family 12 member 3, 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide (3 entities in total) |
Functional Keywords | sodium chloride cotransporter, phosphorylation, thiazide-like diuretics, chlorthalidone, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 227068.06 |
Authors | |
Primary citation | Zhao, Y.,Schubert, H.,Blakely, A.,Forbush, B.,Smith, M.D.,Rinehart, J.,Cao, E. Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15:7006-7006, 2024 Cited by PubMed: 39143061DOI: 10.1038/s41467-024-51381-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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