8VNX

A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds

8VNX の概要

• エントリーDOI: 10.2210/pdb8vnx/pdb
• 分子名称: Mitogen-activated protein kinase 10, (4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide (3 entities in total)
• 機能のキーワード: c-jun terminal kinase 3, jnk3, p38 alpha, kinase, selectivity, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53094.24

構造登録者

Park, H.,Feng, Y. (登録日: 2024-01-13, 公開日: 2025-01-15, 最終更新日: 2026-01-28)

• 主引用文献: Park, H.,Feng, Y.; Structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds; J.Mol.Struct., 1339:142179-, 2025; DOI: 10.1016/j.molstruc.2025.142179

実験手法

X-RAY DIFFRACTION (2 Å)