8VLI

Cryo-EM structure of human HGSNAT bound with CoA and product analog

This is a non-PDB format compatible entry.

Summary for 8VLI

• Entry DOI: 10.2210/pdb8vli/pdb
• EMDB information: 43339
• Descriptor: Heparan-alpha-glucosaminide N-acetyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: membrane protein, lysosome, transmembrane acetyltransferase, coa, product, heperan sulfate, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 150554.31

Authors

Li, F.,Zhao, B. (deposition date: 2024-01-11, release date: 2024-06-26, Last modification date: 2024-10-16)

• Primary citation: Zhao, B.,Cao, Z.,Zheng, Y.,Nguyen, P.,Bowen, A.,Edwards, R.H.,Stroud, R.M.,Zhou, Y.,Van Lookeren Campagne, M.,Li, F.; Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome.; Nat Commun, 15:5388-5388, 2024; PubMed: 38918376; DOI: 10.1038/s41467-024-49614-1

Experimental method

ELECTRON MICROSCOPY (3.2 Å)