8VLG

Cryo-EM structure of human HGSNAT bound with Acetyl-CoA and substrate analog

This is a non-PDB format compatible entry.

Summary for 8VLG

• Entry DOI: 10.2210/pdb8vlg/pdb
• EMDB information: 43338
• Descriptor: Heparan-alpha-glucosaminide N-acetyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: membrane protein, lysosome, transmembrane acetyltransferase, acetyl-coa, substrate, heperan sulfate, transferase-substrate analog complex, transferase-substrate complex, transferase/substrate
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 150333.10

Authors

Li, F.,Zhao, B. (deposition date: 2024-01-11, release date: 2024-06-26)

• Primary citation: Li, F.; Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.15 Å)