8VJP

Histidine-covalent stapled alpha-helical peptide (155H1) targeting hMcl-1

This is a non-PDB format compatible entry.

Summary for 8VJP

• Entry DOI: 10.2210/pdb8vjp/pdb
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Histidine-covalent stapled alpha-helical peptide, (S~1~R)-3-carbamoyl-4-methoxybenzene-1-sulfinic acid, ... (5 entities in total)
• Functional Keywords: histidine-covalent stapled alpha-helical peptides, apoptosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 19609.36

Authors

Muzzarelli, K.M.,Assar, Z.,Alboreggia, G.,Pellecchia, M. (deposition date: 2024-01-07, release date: 2024-05-15, Last modification date: 2024-06-05)

• Primary citation: Alboreggia, G.,Udompholkul, P.,Baggio, C.,Muzzarelli, K.,Assar, Z.,Pellecchia, M.; Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1.; J.Med.Chem., 67:8172-8185, 2024; PubMed: 38695666; DOI: 10.1021/acs.jmedchem.4c00277

Experimental method