8VIW

Cryo-EM structure of heparosan synthase 2 from Pasteurella multocida with polysaccharide in the GlcNAc-T active site

8VIW の概要

• エントリーDOI: 10.2210/pdb8viw/pdb
• 関連するPDBエントリー: 8VH7 8VH8
• EMDBエントリー: 43269
• 分子名称: Heparosan synthase B, beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, MANGANESE (II) ION, ... (5 entities in total)
• 機能のキーワード: polysaccharide synthase, complex, transferase
• 由来する生物種: Pasteurella multocida
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 265981.20

構造登録者

Krahn, J.M.,Pedersen, L.C.,Liu, J.,Stancanelli, E.,Borgnia, M.,Vivarette, E. (登録日: 2024-01-05, 公開日: 2024-07-24)

• 主引用文献: Stancanelli, E.,Krahn, J.A.,Viverette, E.,Dutcher, R.,Pagadala, V.,Borgnia, M.J.,Liu, J.,Pedersen, L.C.; Structural and Functional Analysis of Heparosan Synthase 2 from Pasteurella multocida to Improve the Synthesis of Heparin; Acs Catalysis, 14:6577-6588, 2024; DOI: 10.1021/acscatal.4c00677

実験手法

ELECTRON MICROSCOPY (3.3 Å)