Summary for 8VHL
Entry DOI | 10.2210/pdb8vhl/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total) |
Functional Keywords | dihydroorotate dehydrogenase, dhodh, oxidoreductase, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41940.65 |
Authors | |
Primary citation | DeRatt, L.G.,Pietsch, E.C.,Cisar, J.S.,Jacoby, E.,Kazmi, F.,Matico, R.,Shaffer, P.,Tanner, A.,Wang, W.,Attar, R.,Edwards, J.P.,Kuduk, S.D. Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors. Acs Med.Chem.Lett., 15:381-387, 2024 Cited by PubMed: 38505861DOI: 10.1021/acsmedchemlett.3c00543 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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