8VHH

Engineered holo tryptophan synthase (Tm9D8*) derived from T. maritima TrpB

Summary for 8VHH

Entry DOI	10.2210/pdb8vhh/pdb
Descriptor	Tryptophan synthase beta chain 1, PYRIDOXAL-5'-PHOSPHATE, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	enzyme, synthase, tryptophan synthases, engineered enzyme, lyase
Biological source	Thermotoga maritima
Total number of polymer chains	2
Total formula weight	88767.71
Authors	Porter, N.J.,Johnston, K.E.,Almhjell, P.J.,Arnold, F.H. (deposition date: 2024-01-02, release date: 2024-08-14)
Primary citation	Johnston, K.E.,Almhjell, P.J.,Watkins-Dulaney, E.J.,Liu, G.,Porter, N.J.,Yang, J.,Arnold, F.H. A combinatorially complete epistatic fitness landscape in an enzyme active site. Proc.Natl.Acad.Sci.USA, 121:e2400439121-e2400439121, 2024 Cited by PubMed: 39074291 DOI: 10.1073/pnas.2400439121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation