8VHE

Crystal Structure of Human IDH1 R132Q in Complex with NADPH-TCEP Adduct

This is a non-PDB format compatible entry.

Summary for 8VHE

• Entry DOI: 10.2210/pdb8vhe/pdb
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, 3,3',3''-({(4R)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1,4-dihydropyridin-4-yl}-lambda~5~-phosphanetriyl)tripropanoic acid, GLYCEROL, ... (7 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 199288.11

Authors

Mealka, M.,Sohl, C.D.,Huxford, T. (deposition date: 2023-12-31, release date: 2024-04-24, Last modification date: 2024-05-22)

• Primary citation: Mealka, M.,Sierra, N.A.,Avellaneda Matteo, D.,Albekioni, E.,Khoury, R.,Mai, T.,Conley, B.M.,Coleman, N.J.,Sabo, K.A.,Komives, E.A.,Bobkov, A.A.,Cooksy, A.L.,Silletti, S.,Schiffer, J.M.,Huxford, T.,Sohl, C.D.; Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.; Nat Commun, 15:3785-3785, 2024; PubMed: 38710674; DOI: 10.1038/s41467-024-48277-2

Experimental method

X-RAY DIFFRACTION (2.16 Å)