8VFU
The Fab Crystal Structure of the PAN IL-1 Family Inhibitor Antibody 3G5
Summary for 8VFU
Entry DOI | 10.2210/pdb8vfu/pdb |
Descriptor | 3G5 Light Chain, 3G5 Heavy Chain (3 entities in total) |
Functional Keywords | fab, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 48501.95 |
Authors | Fields, J.K.,Sundberg, E.J. (deposition date: 2023-12-22, release date: 2024-02-21, Last modification date: 2024-06-19) |
Primary citation | Fields, J.K.,Gyllenback, E.J.,Bogacz, M.,Obi, J.,Birkedal, G.S.,Sjostrom, K.,Maravillas, K.,Gronberg, C.,Rattik, S.,Kihn, K.,Flowers, M.,Smith, A.K.,Hansen, N.,Fioretos, T.,Huyhn, C.,Liberg, D.,Deredge, D.,Sundberg, E.J. Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling. Cell Rep, 43:114099-114099, 2024 Cited by PubMed: 38636519DOI: 10.1016/j.celrep.2024.114099 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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