8VFU

The Fab Crystal Structure of the PAN IL-1 Family Inhibitor Antibody 3G5

Summary for 8VFU

Entry DOI	10.2210/pdb8vfu/pdb
Descriptor	3G5 Light Chain, 3G5 Heavy Chain (3 entities in total)
Functional Keywords	fab, immune system
Biological source	Homo sapiens More
Total number of polymer chains	2
Total formula weight	48501.95
Authors	Fields, J.K.,Sundberg, E.J. (deposition date: 2023-12-22, release date: 2024-02-21, Last modification date: 2024-06-19)
Primary citation	Fields, J.K.,Gyllenback, E.J.,Bogacz, M.,Obi, J.,Birkedal, G.S.,Sjostrom, K.,Maravillas, K.,Gronberg, C.,Rattik, S.,Kihn, K.,Flowers, M.,Smith, A.K.,Hansen, N.,Fioretos, T.,Huyhn, C.,Liberg, D.,Deredge, D.,Sundberg, E.J. Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling. Cell Rep, 43:114099-114099, 2024 Cited by PubMed: 38636519 DOI: 10.1016/j.celrep.2024.114099 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation