8VBV
Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Cephalexin) inhibited form
Summary for 8VBV
Entry DOI | 10.2210/pdb8vbv/pdb |
Descriptor | Penicillin-binding protein 1, (2S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid (3 entities in total) |
Functional Keywords | penicillin binding protein 1, peptidoglycan transpeptidase domain, pedestal domain, membrane protein, hydrolase-inhibitor, antibiotic complex, hydrolase/inhibitor, antibiotic |
Biological source | Staphylococcaceae bacterium |
Total number of polymer chains | 2 |
Total formula weight | 133987.33 |
Authors | Bon, C.G.,Lee, J.,Caveney, N.A.,Strynadka, N.C.J. (deposition date: 2023-12-12, release date: 2024-05-01) |
Primary citation | Bon, C.G.,Grigg, J.C.,Lee, J.,Robb, C.S.,Caveney, N.A.,Eltis, L.D.,Strynadka, N.C.J. Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216:108086-108086, 2024 Cited by PubMed: 38527711DOI: 10.1016/j.jsb.2024.108086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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