8VB5

Crystal structure of kinase domain of HER2 Exon 20 insertion mutant in complex with tucatinib

This is a non-PDB format compatible entry.

Summary for 8VB5

• Entry DOI: 10.2210/pdb8vb5/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-2, Tucatinib, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: receptor tyrosine kinase, yvma insertion, alpha-c helix, a-loop, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 39688.09

Authors

Rana, N.,Campbell, J.,Dou, Y. (deposition date: 2023-12-12, release date: 2024-12-18)

• Primary citation: Rana, N.,Campbell, J.,Dou, Y.; Crystal structure of kinase domain of HER2 Exon 20 insertion mutant in complex with tucatinib; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.48 Å)