8V8Z

Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3473329

This is a non-PDB format compatible entry.

Summary for 8V8Z

• Entry DOI: 10.2210/pdb8v8z/pdb
• Related: 8TCE
• Descriptor: Apolipoprotein(a), muvalaplin (3 entities in total)
• Functional Keywords: complex, inhibitor, ldl, lipid binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 33405.15

Authors

Hendle, J.,Weichert, K.,Sauder, J.M. (deposition date: 2023-12-06, release date: 2024-05-08, Last modification date: 2024-06-19)

• Primary citation: Diaz, N.,Perez, C.,Escribano, A.M.,Sanz, G.,Priego, J.,Lafuente, C.,Barberis, M.,Calle, L.,Espinosa, J.F.,Priest, B.T.,Zhang, H.Y.,Nosie, A.K.,Haas, J.V.,Cannady, E.,Borel, A.,Schultze, A.E.,Sauder, J.M.,Hendle, J.,Weichert, K.,Nicholls, S.J.,Michael, L.F.; Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.; Nature, 629:945-950, 2024; PubMed: 38720069; DOI: 10.1038/s41586-024-07387-z

Experimental method

X-RAY DIFFRACTION (2.01 Å)