8V5U

Human SIRT3 bound to p53-AMC peptide and Honokiol

Summary for 8V5U

• Entry DOI: 10.2210/pdb8v5u/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, p53-AMC peptide, ZINC ION, ... (5 entities in total)
• Functional Keywords: activator, complex, deacylase, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 32371.64

Authors

Chakrabarti, R.,Ghosh, A.,Guan, X.,Upadhyay, A.,Dumpati, R.K.,Munshi, S.,Roy, S.,Chall, S.,Rahnamoun, A.,Reverdy, C.,Errasti, G.,Delacroix, T. (deposition date: 2023-12-01, release date: 2024-11-06)

• Primary citation: Guan, X.,Dumpati, R.K.,Munshi, S.,Chall, S.,Bose, R.,Rahnamoun, A.,Reverdy, C.,Errasti, G.,Delacroix, T.,Ghosh, A.,Chakrabarti, R.; Computationally Driven Discovery and Characterization of SIRT3-Activating Compounds that Fully Recover Catalytic Activity under ${\mathrm{NAD}}^{+}$ Depletion; Phys. Rev. X, 14:-, 2024; DOI: 10.1103/PhysRevX.14.041019

Experimental method

X-RAY DIFFRACTION (1.48 Å)