8V4S

Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium

Summary for 8V4S

• Entry DOI: 10.2210/pdb8v4s/pdb
• Related: 8TR5 8TRJ
• EMDB information: 41570 41581 42976
• Descriptor: P2X purinoceptor 7, GUANOSINE-5'-DIPHOSPHATE, ZINC ION, ... (6 entities in total)
• Functional Keywords: membrane protein, ion channel, ligand-gate ion channel, p2x receptor, allosteric antagonist, high-affinity agonist
• Biological source: Rattus; More
• Total number of polymer chains: 3
• Total formula weight: 212976.67

Authors

Oken, A.C.,Lisi, N.E.,Krishnamurthy, I.,McCarthy, A.E.,Godsey, M.H.,Glasfeld, A.,Mansoor, S.E. (deposition date: 2023-11-29, release date: 2024-08-14)

• Primary citation: Oken, A.C.,Lisi, N.E.,Krishnamurthy, I.,McCarthy, A.E.,Godsey, M.H.,Glasfeld, A.,Mansoor, S.E.; High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket; Nat Commun, 2024; DOI: 10.1038/s41467-024-50771-6

Experimental method