8V1T
Herpes simplex virus 1 polymerase holoenzyme bound to DNA and acyclovir triphosphate in closed conformation
Summary for 8V1T
Entry DOI | 10.2210/pdb8v1t/pdb |
EMDB information | 28663 28664 42887 42888 42889 42890 42891 |
Descriptor | DNA polymerase, DNA polymerase processivity factor, PRIMER DNA (32-MER), ... (7 entities in total) |
Functional Keywords | herpes simplex virus, replication, dna polymerase, acyclovir, antiherpesvirus drug, transferase-dna complex, transferase/dna |
Biological source | Human alphaherpesvirus 1 strain KOS More |
Total number of polymer chains | 4 |
Total formula weight | 195589.01 |
Authors | Pan, J.,Abraham, J.,Coen, D.M.,Shankar, S.,Yang, P.,Hogle, J. (deposition date: 2023-11-21, release date: 2024-09-04, Last modification date: 2024-09-18) |
Primary citation | Shankar, S.,Pan, J.,Yang, P.,Bian, Y.,Oroszlan, G.,Yu, Z.,Mukherjee, P.,Filman, D.J.,Hogle, J.M.,Shekhar, M.,Coen, D.M.,Abraham, J. Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance. Cell, 2024 Cited by PubMed: 39197451DOI: 10.1016/j.cell.2024.07.048 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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