8V1T

Herpes simplex virus 1 polymerase holoenzyme bound to DNA and acyclovir triphosphate in closed conformation

8V1T の概要

• エントリーDOI: 10.2210/pdb8v1t/pdb
• EMDBエントリー: 28663 28664 42887 42888 42889 42890 42891
• 分子名称: DNA polymerase, DNA polymerase processivity factor, PRIMER DNA (32-MER), ... (7 entities in total)
• 機能のキーワード: herpes simplex virus, replication, dna polymerase, acyclovir, antiherpesvirus drug, transferase-dna complex, transferase/dna
• 由来する生物種: Human alphaherpesvirus 1 strain KOS; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 195589.01

構造登録者

Pan, J.,Abraham, J.,Coen, D.M.,Shankar, S.,Yang, P.,Hogle, J. (登録日: 2023-11-21, 公開日: 2024-09-04)

• 主引用文献: Shankar, S.,Pan, J.,Yang, P.,Bian, Y.,Oroszlan, G.,Yu, Z.,Mukherjee, P.,Filman, D.J.,Hogle, J.,Shekhar, M.,Coen, D.M.,Abraham, J.; Viral DNA polymerase structures reveal mechanisms for drug selectivity; Cell(Cambridge,Mass.), 2024; DOI: 10.1016/j.cell.2024.07.048

実験手法

ELECTRON MICROSCOPY (2.8 Å)