8V0Z

HIV-1 Integrase F185H W131C Complexed with Allosteric Inhibitor BI-D

Summary for 8V0Z

• Entry DOI: 10.2210/pdb8v0z/pdb
• Related: 5HOT 8USY
• Descriptor: Integrase, (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid (2 entities in total)
• Functional Keywords: hiv-1, viral protein, hiv-1 integrase, allosteric inhibitor, allini, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 66133.48

Authors

Montermoso, S.,Gupta, K.,Eilers, G.,Bushman, F.D.,Van Duyne, G.D. (deposition date: 2023-11-18, release date: 2025-03-19)

• Primary citation: Montermoso, S.,Gupta, K.,Eilers, G.,Allen, A.,Stewart, N.,Gore, A.,An, N.,Hwang, Y.,Sharp, R.,Bushman, F.D.,Van Duyne, G.D.; Structural Consequences of Resistance Mutations on the Formation of ALLINI-Induced Branched Polymers of HIV-1 Integrase; To Be Published,

Experimental method

X-RAY DIFFRACTION (4.56 Å)