8UY2
Methylenetetrahydrofolate reductase from Chaetomium thermophilum DSM 1495, AdoMet-bound, Inhibited (T) State
Summary for 8UY2
Entry DOI | 10.2210/pdb8uy2/pdb |
Descriptor | Methylenetetrahydrofolate reductase-like protein, FLAVIN-ADENINE DINUCLEOTIDE, S-ADENOSYLMETHIONINE, ... (8 entities in total) |
Functional Keywords | methylenetetrahydrofolate reductase, nadph activity, oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor cobalamin binding, one-carbon metabolism, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Thermochaetoides thermophila DSM 1495 |
Total number of polymer chains | 4 |
Total formula weight | 288663.74 |
Authors | Yamada, K.,Mendoza, J.,Koutmos, M. (deposition date: 2023-11-12, release date: 2024-06-19, Last modification date: 2024-07-03) |
Primary citation | Yamada, K.,Mendoza, J.,Koutmos, M. Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase. Nat Commun, 15:5167-5167, 2024 Cited by PubMed: 38886362DOI: 10.1038/s41467-024-49327-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.83 Å) |
Structure validation
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