8UY2

Methylenetetrahydrofolate reductase from Chaetomium thermophilum DSM 1495, AdoMet-bound, Inhibited (T) State

8UY2 の概要

• エントリーDOI: 10.2210/pdb8uy2/pdb
• 分子名称: Methylenetetrahydrofolate reductase-like protein, FLAVIN-ADENINE DINUCLEOTIDE, S-ADENOSYLMETHIONINE, ... (8 entities in total)
• 機能のキーワード: methylenetetrahydrofolate reductase, nadph activity, oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor cobalamin binding, one-carbon metabolism, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Thermochaetoides thermophila DSM 1495
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 288663.74

構造登録者

Yamada, K.,Mendoza, J.,Koutmos, M. (登録日: 2023-11-12, 公開日: 2024-06-19, 最終更新日: 2024-07-03)

• 主引用文献: Yamada, K.,Mendoza, J.,Koutmos, M.; Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase.; Nat Commun, 15:5167-5167, 2024; PubMed: 38886362; DOI: 10.1038/s41467-024-49327-5

実験手法

X-RAY DIFFRACTION (2.83 Å)