8UY1

Methylenetetrahydrofolate reductase from Chaetomium thermophilum DSM 1495, Active (R) State

Summary for 8UY1

Entry DOI	10.2210/pdb8uy1/pdb
Descriptor	Methylenetetrahydrofolate reductase-like protein, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywords	methylenetetrahydrofolate reductase, nadph activity, oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor cobalamin binding, one-carbon metabolism, oxidoreductase
Biological source	Thermochaetoides thermophila DSM 1495
Total number of polymer chains	4
Total formula weight	284773.17
Authors	Yamada, K.,Mendoza, J.,Koutmos, M. (deposition date: 2023-11-12, release date: 2024-06-19, Last modification date: 2024-07-03)
Primary citation	Yamada, K.,Mendoza, J.,Koutmos, M. Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase. Nat Commun, 15:5167-5167, 2024 Cited by PubMed: 38886362 DOI: 10.1038/s41467-024-49327-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.49 Å)

Structure validation