8UVS

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution

これはPDB形式変換不可エントリーです。

8UVS の概要

• エントリーDOI: 10.2210/pdb8uvs/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• 機能のキーワード: spectinomycin; aminomethyl spectinomycin; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; infectious diseases; antimicrobial drug discovery; semisynthetic chemistry; drug development, ribosome, ribosome-inhibitor complex, ribosome/inhibitor
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 112
• 化学式量合計: 4572867.66

構造登録者

Killam, B.Y.,Phelps, G.A.,Lee, R.E.,Polikanov, Y.S. (登録日: 2023-11-03, 公開日: 2024-08-07)

• 主引用文献: Phelps, G.A.,Cheramie, M.N.,Fernando, D.M.,Selchow, P.,Meyer, C.J.,Waidyarachchi, S.L.,Dharuman, S.,Liu, J.,Meuli, M.,Molin, M.D.,Killam, B.Y.,Murphy, P.A.,Reeve, S.M.,Wilt, L.A.,Anderson, S.M.,Yang, L.,Lee, R.B.,Temrikar, Z.H.,Lukka, P.B.,Meibohm, B.,Polikanov, Y.S.,Hobbie, S.N.,Bottger, E.C.,Sander, P.,Lee, R.E.; Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.; Proc.Natl.Acad.Sci.USA, 121:e2314101120-e2314101120, 2024; PubMed: 38165935; DOI: 10.1073/pnas.2314101120

実験手法

X-RAY DIFFRACTION (2.75 Å)