8UV0

Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2

Summary for 8UV0

Entry DOI	10.2210/pdb8uv0/pdb
Descriptor	Cyclin-dependent kinase 2, 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol (3 entities in total)
Functional Keywords	cdk2, serine/threonine kinase, cell cycle regulation, aminopyrimidine, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34333.82
Authors	Deller, M.C.,Epling, L.B. (deposition date: 2023-11-02, release date: 2024-02-14, Last modification date: 2024-03-06)
Primary citation	Hummel, J.R.,Xiao, K.J.,Yang, J.C.,Epling, L.B.,Mukai, K.,Ye, Q.,Xu, M.,Qian, D.,Huo, L.,Weber, M.,Roman, V.,Lo, Y.,Drake, K.,Stump, K.,Covington, M.,Kapilashrami, K.,Zhang, G.,Ye, M.,Diamond, S.,Yeleswaram, S.,Macarron, R.,Deller, M.C.,Wee, S.,Kim, S.,Wang, X.,Wu, L.,Yao, W. Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2. J.Med.Chem., 67:3112-3126, 2024 Cited by PubMed: 38325398 DOI: 10.1021/acs.jmedchem.3c02287 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation