8UV0

Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2

8UV0 の概要

• エントリーDOI: 10.2210/pdb8uv0/pdb
• 分子名称: Cyclin-dependent kinase 2, 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol (3 entities in total)
• 機能のキーワード: cdk2, serine/threonine kinase, cell cycle regulation, aminopyrimidine, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34333.82

構造登録者

Deller, M.C.,Epling, L.B. (登録日: 2023-11-02, 公開日: 2024-02-14, 最終更新日: 2024-03-06)

• 主引用文献: Hummel, J.R.,Xiao, K.J.,Yang, J.C.,Epling, L.B.,Mukai, K.,Ye, Q.,Xu, M.,Qian, D.,Huo, L.,Weber, M.,Roman, V.,Lo, Y.,Drake, K.,Stump, K.,Covington, M.,Kapilashrami, K.,Zhang, G.,Ye, M.,Diamond, S.,Yeleswaram, S.,Macarron, R.,Deller, M.C.,Wee, S.,Kim, S.,Wang, X.,Wu, L.,Yao, W.; Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.; J.Med.Chem., 67:3112-3126, 2024; PubMed: 38325398; DOI: 10.1021/acs.jmedchem.3c02287

実験手法

X-RAY DIFFRACTION (1.55 Å)