8UTT
KIF1A[1-393] P305L mutant AMP-PNP bound two-heads-bound state in complex with a microtubule
Summary for 8UTT
Entry DOI | 10.2210/pdb8utt/pdb |
EMDB information | 42549 |
Descriptor | Kinesin-like protein KIF1A, Tubulin alpha-1B chain, Tubulin beta-2B chain, ... (8 entities in total) |
Functional Keywords | kif1a, kinesin, motility, microtubule, tubulin, motor protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 7 |
Total formula weight | 354495.43 |
Authors | Benoit, M.P.M.H.,Rao, L.,Asenjo, A.B.,Gennerich, A.,Sosa, H. (deposition date: 2023-10-31, release date: 2024-06-12, Last modification date: 2024-07-31) |
Primary citation | Benoit, M.P.M.H.,Rao, L.,Asenjo, A.B.,Gennerich, A.,Sosa, H. Cryo-EM unveils kinesin KIF1A's processivity mechanism and the impact of its pathogenic variant P305L. Nat Commun, 15:5530-5530, 2024 Cited by PubMed: 38956021DOI: 10.1038/s41467-024-48720-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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