8UQD

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (condition 2. RING not modeled in density)

8UQD の概要

• エントリーDOI: 10.2210/pdb8uqd/pdb
• 分子名称: E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E (1 entity in total)
• 機能のキーワード: rnf168, ubch5c, histone h2a, histone h2b, chromatin, ubiquitin ligase, ubiquitin-conjugating enzyme, dna damage response, dna double-strand break repair, protein binding, protein binding-transferase complex, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50040.32

構造登録者

Hu, Q.,Botuyan, M.V.,Mer, G. (登録日: 2023-10-23, 公開日: 2024-01-17, 最終更新日: 2024-03-20)

• 主引用文献: Hu, Q.,Zhao, D.,Cui, G.,Bhandari, J.,Thompson, J.R.,Botuyan, M.V.,Mer, G.; Mechanisms of RNF168 nucleosome recognition and ubiquitylation.; Mol.Cell, 84:839-853.e12, 2024; PubMed: 38242129; DOI: 10.1016/j.molcel.2023.12.036

実験手法

X-RAY DIFFRACTION (3.893 Å)