8UOS

Designed IL-1R antagonist IL-1Rmb80

Summary for 8UOS

Entry DOI	10.2210/pdb8uos/pdb
Descriptor	IL-1Rmb80, GLYCEROL (3 entities in total)
Functional Keywords	protein design, antagonist, immune system, de novo protein
Biological source	synthetic construct
Total number of polymer chains	4
Total formula weight	30945.72
Authors	Jude, K.M.,Garcia, K.C. (deposition date: 2023-10-20, release date: 2024-08-28)
Primary citation	Huang, B.,Coventry, B.,Borowska, M.T.,Arhontoulis, D.C.,Exposit, M.,Abedi, M.,Jude, K.M.,Halabiya, S.F.,Allen, A.,Cordray, C.,Goreshnik, I.,Ahlrichs, M.,Chan, S.,Tunggal, H.,DeWitt, M.,Hyams, N.,Carter, L.,Stewart, L.,Fuller, D.H.,Mei, Y.,Garcia, K.C.,Baker, D. De novo design of miniprotein antagonists of cytokine storm inducers. Nat Commun, 15:7064-7064, 2024 Cited by PubMed: 39152100 DOI: 10.1038/s41467-024-50919-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation