8ULZ

LSD1-CoREST in complex with T18 and SNAG peptide

Summary for 8ULZ

Entry DOI	10.2210/pdb8ulz/pdb
Descriptor	Zinc finger protein SNAI1, Lysine-specific histone demethylase 1A, REST corepressor 1, ... (4 entities in total)
Functional Keywords	epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	113652.57
Authors	Caroli, J.,Mattevi, A. (deposition date: 2023-10-17, release date: 2025-08-27)
Primary citation	Caroli, J.,Mattevi, A. Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 To Be Published,
Experimental method	X-RAY DIFFRACTION (3.32 Å)

Structure validation