8ULC

LSD1-CoREST in complex with T15, long soaking

Summary for 8ULC

• Entry DOI: 10.2210/pdb8ulc/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, methyl 3-{(1R,3S,3aS,13R)-8-[(2S,3S,4R)-5-{[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-2,3,4-trihydroxypentyl]-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,4,5,6,8-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-3-yl}benzoate (non-preferred name) (3 entities in total)
• Functional Keywords: epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 112489.14

Authors

Caroli, J.,Mattevi, A. (deposition date: 2023-10-16, release date: 2025-02-05)

• Primary citation: Caroli, J.,Mattevi, A.; Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.82 Å)