8UKY

Crystal structure of BAK in complex with inhibiting antibody 14G6

Summary for 8UKY

• Entry DOI: 10.2210/pdb8uky/pdb
• Descriptor: 14G6 Fab light chain, PENTAETHYLENE GLYCOL, 14G6 Fab heavy chain, ... (11 entities in total)
• Functional Keywords: bak, apoptosis-inhibitor complex, bcl2, antibody, apoptosis/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 133361.64

Authors

Miller, M.S.,Czabotar, P.E. (deposition date: 2023-10-15, release date: 2024-04-10, Last modification date: 2024-04-17)

• Primary citation: Subas Satish, H.P.,Iyer, S.,Shi, M.X.,Wong, A.W.,Fischer, K.C.,Wardak, A.Z.,Lio, D.,Brouwer, J.M.,Uren, R.T.,Czabotar, P.E.,Miller, M.S.,Kluck, R.M.; A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells.; Cell Death Differ., 2024; PubMed: 38582955; DOI: 10.1038/s41418-024-01289-3

Experimental method

X-RAY DIFFRACTION (2.398 Å)