8UFD

Multidrug efflux pump MtEfpA bound with inhibitor BRD8000.3

Summary for 8UFD

• Entry DOI: 10.2210/pdb8ufd/pdb
• Related: 8WM5
• EMDB information: 42204
• Descriptor: Integral membrane efflux protein EFPA, PHOSPHATIDYLETHANOLAMINE, (1S,3S)-N-[6-bromo-5-(pyrimidin-2-yl)pyridin-2-yl]-2,2-dimethyl-3-(2-methylpropyl)cyclopropane-1-carboxamide (3 entities in total)
• Functional Keywords: multidrug efflux pump, efpa, mycobacterium, brd8000.3, transport protein
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 114982.98

Authors

Wang, S.,Liao, M. (deposition date: 2023-10-04, release date: 2024-09-11)

• Primary citation: Wang, S.,Wang, K.,Song, K.,Lai, Z.W.,Li, P.,Li, D.,Sun, Y.,Mei, Y.,Xu, C.,Liao, M.; Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition.; Nat Commun, 15:7710-7710, 2024; PubMed: 39231991; DOI: 10.1038/s41467-024-51948-9

Experimental method

ELECTRON MICROSCOPY (3.26 Å)