8UDZ

The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex

Summary for 8UDZ

• Entry DOI: 10.2210/pdb8udz/pdb
• Descriptor: Transforming growth factor beta-1 proprotein, LTBP-49247 Fab Heavy Chain, LTBP-49247 Fab Light Chain, ... (6 entities in total)
• Functional Keywords: growth factor, antibody, fibrosis, tgfbeta, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 180965.25

Authors

Streich Jr., F.C.,Nicholls, S.B.,Boston, C.J.,Ramachandran, S. (deposition date: 2023-09-29, release date: 2024-07-17)

• Primary citation: Jackson, J.W.,Streich Jr., F.C.,Pal, A.,Coricor, G.,Boston, C.,Brueckner, C.T.,Canonico, K.,Chapron, C.,Cote, S.,Dagbay, K.B.,Danehy Jr., F.T.,Kavosi, M.,Kumar, S.,Lin, S.,Littlefield, C.,Looby, K.,Manohar, R.,Martin, C.J.,Wood, M.,Zawadzka, A.,Wawersik, S.,Nicholls, S.B.,Datta, A.,Buckler, A.,Schurpf, T.,Carven, G.J.,Qatanani, M.,Fogel, A.I.; An antibody that inhibits TGF-beta 1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis.; Sci.Signal., 17:eadn6052-eadn6052, 2024; PubMed: 38980922; DOI: 10.1126/scisignal.adn6052

Experimental method

X-RAY DIFFRACTION (2.21 Å)