8UD6

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution

これはPDB形式変換不可エントリーです。

8UD6 の概要

• エントリーDOI: 10.2210/pdb8ud6/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• 機能のキーワード: cresomycin, lincosamides, structure-based drug design, antibiotic, resistance, cfr, erm, methylation, a2058, a2503, 23s rrna, 70s ribosome, inhibition of translation, peptidyl transferase center, nascent peptide exit tunnel, ribosome, ribosome-rna complex, ribosome/rna
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 112
• 化学式量合計: 4566181.86

構造登録者

Aleksandrova, E.V.,Syroegin, E.A.,Wu, K.J.Y.,Tresco, B.I.C.,Ramkissoon, A.,See, D.N.Y.,Liow, P.,Dittemore, G.A.,Yu, M.,Testolin, G.,Mitcheltree, M.J.,Liu, R.Y.,Svetlov, M.S.,Myers, A.G.,Polikanov, Y.S. (登録日: 2023-09-28, 公開日: 2024-02-21, 最終更新日: 2024-02-28)

• 主引用文献: Wu, K.J.Y.,Tresco, B.I.C.,Ramkissoon, A.,Aleksandrova, E.V.,Syroegin, E.A.,See, D.N.Y.,Liow, P.,Dittemore, G.A.,Yu, M.,Testolin, G.,Mitcheltree, M.J.,Liu, R.Y.,Svetlov, M.S.,Polikanov, Y.S.,Myers, A.G.; An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.; Science, 383:721-726, 2024; PubMed: 38359125; DOI: 10.1126/science.adk8013

実験手法

X-RAY DIFFRACTION (2.7 Å)