8UC7

HCN1 complex with propofol

Summary for 8UC7

• Entry DOI: 10.2210/pdb8uc7/pdb
• EMDB information: 42116 42117
• Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, 2,6-BIS(1-METHYLETHYL)PHENOL, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (3 entities in total)
• Functional Keywords: inhibitor, complex, plasma membrane, cyclic nucleotide, transport protein-inhibitor complex, transport protein/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 308733.47

Authors

Kim, E.D.,Nimigean, C.M. (deposition date: 2023-09-25, release date: 2024-07-31)

• Primary citation: Kim, E.D.,Wu, X.,Lee, S.,Tibbs, G.R.,Cunningham, K.P.,Perez, M.E.,Goldstein, P.A.,Accardi, A.,Larsson, H.P.,Nimigean, C.M.; Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants; Nature, 2024; DOI: 10.1038/s41586-024-07743-z

Experimental method

ELECTRON MICROSCOPY (2.9 Å)