8U8A

Cryo-EM structure of LRRK2 bound to type II inhibitor ponatinib

8U8A の概要

• エントリーDOI: 10.2210/pdb8u8a/pdb
• EMDBエントリー: 42019
• 分子名称: Leucine-rich repeat serine/threonine-protein kinase 2, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
• 機能のキーワード: cryo-em, parkinson's disease, kinase, lrrk2, type ii inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 574806.83

構造登録者

Zhu, H.,Sun, J. (登録日: 2023-09-16, 公開日: 2024-01-31)

• 主引用文献: Zhu, H.,Hixson, P.,Ma, W.,Sun, J.; Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM.; Cell Discov, 10:10-10, 2024; PubMed: 38263358; DOI: 10.1038/s41421-023-00639-8

実験手法

ELECTRON MICROSCOPY (3.4 Å)