8U7V
Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+, interface-centered
Summary for 8U7V
Entry DOI | 10.2210/pdb8u7v/pdb |
Related | 8U7M 8U7Q |
EMDB information | 42012 |
Descriptor | Inosine-5'-monophosphate dehydrogenase 1, GUANOSINE-5'-TRIPHOSPHATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | dehydrogenase, nucleotide synthesis, filament, phosphomimetic, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 8 |
Total formula weight | 488864.62 |
Authors | Calise, S.J.,Kollman, J.M. (deposition date: 2023-09-15, release date: 2024-01-31, Last modification date: 2024-02-14) |
Primary citation | Calise, S.J.,O'Neill, A.G.,Burrell, A.L.,Dickinson, M.S.,Molfino, J.,Clarke, C.,Quispe, J.,Sokolov, D.,Buey, R.M.,Kollman, J.M. Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly. J.Cell Biol., 223:-, 2024 Cited by PubMed: 38323936DOI: 10.1083/jcb.202310139 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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