8U6X

ATP-dependent DNA ligase Lig E from Neisseria gonorrhoeae

Summary for 8U6X

• Entry DOI: 10.2210/pdb8u6x/pdb
• Descriptor: DNA ligase, DNA (5'-D(*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*GP*AP*CP*CP*CP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*A)-3'), ... (6 entities in total)
• Functional Keywords: enzyme-adenylate, lig e, ligase, ligase-dna complex, ligase/dna
• Biological source: Neisseria gonorrhoeae MS11; More
• Total number of polymer chains: 3
• Total formula weight: 45437.17

Authors

Williamson, A.,Pan, J. (deposition date: 2023-09-14, release date: 2024-01-31, Last modification date: 2024-10-16)

Primary citation

Pan, J.,Singh, A.,Hanning, K.,Hicks, J.,Williamson, A.
A role for the ATP-dependent DNA ligase lig E of Neisseria gonorrhoeae in biofilm formation.
Bmc Microbiol., 24:29-29, 2024

PubMed Abstract: The ATP-dependent DNA ligase Lig E is present as an accessory DNA ligase in numerous proteobacterial genomes, including many disease-causing species. Here we have constructed a genomic Lig E knock-out in the obligate human pathogen Neisseria gonorrhoeae and characterised its growth and infection phenotype.

PubMed: 38245708
DOI: 10.1186/s12866-024-03193-9

Experimental method

X-RAY DIFFRACTION (2.44 Å)