8U6X

ATP-dependent DNA ligase Lig E from Neisseria gonorrhoeae

8U6X の概要

• エントリーDOI: 10.2210/pdb8u6x/pdb
• 分子名称: DNA ligase, DNA (5'-D(*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*GP*AP*CP*CP*CP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*A)-3'), ... (6 entities in total)
• 機能のキーワード: enzyme-adenylate, lig e, ligase, ligase-dna complex, ligase/dna
• 由来する生物種: Neisseria gonorrhoeae MS11; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45437.17

構造登録者

Williamson, A.,Pan, J. (登録日: 2023-09-14, 公開日: 2024-01-31, 最終更新日: 2024-10-16)

主引用文献

Pan, J.,Singh, A.,Hanning, K.,Hicks, J.,Williamson, A.
A role for the ATP-dependent DNA ligase lig E of Neisseria gonorrhoeae in biofilm formation.
Bmc Microbiol., 24:29-29, 2024

PubMed Abstract: The ATP-dependent DNA ligase Lig E is present as an accessory DNA ligase in numerous proteobacterial genomes, including many disease-causing species. Here we have constructed a genomic Lig E knock-out in the obligate human pathogen Neisseria gonorrhoeae and characterised its growth and infection phenotype.

PubMed: 38245708
DOI: 10.1186/s12866-024-03193-9

実験手法

X-RAY DIFFRACTION (2.44 Å)