8U6N
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 3-(2-((6-cyanonaphthalen-1-yl)oxy)phenoxy)-N,N-dimethylpropanamide (JLJ752), a non-nucleoside inhibitor
Summary for 8U6N
Entry DOI | 10.2210/pdb8u6n/pdb |
Descriptor | Gag-Pol polyprotein, p51 RT, 3-{2-[(6-cyanonaphthalen-1-yl)oxy]phenoxy}-N,N-dimethylpropanamide, ... (4 entities in total) |
Functional Keywords | reverse transcriptase, antiviral, drug design, hiv-1, viral protein |
Biological source | Human immunodeficiency virus type 1 BH10 More |
Total number of polymer chains | 2 |
Total formula weight | 112624.16 |
Authors | Prucha, G.,Henry, S.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2023-09-13, release date: 2023-11-08) |
Primary citation | Prucha, G.R.,Henry, S.,Hollander, K.,Carter, Z.J.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262:115894-115894, 2023 Cited by PubMed: 37883896DOI: 10.1016/j.ejmech.2023.115894 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
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