8U5M

Structure of Sts-1 HP domain with rebamipide

8U5M の概要

• エントリーDOI: 10.2210/pdb8u5m/pdb
• 分子名称: Ubiquitin-associated and SH3 domain-containing protein B, Rebamipide (3 entities in total)
• 機能のキーワード: sts-1, histidine phosphatase, inhibitor, ubash3b, tula-2, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 193698.86

構造登録者

Azia, F.,Dey, R.,French, J.B. (登録日: 2023-09-12, 公開日: 2024-02-07, 最終更新日: 2024-02-21)

• 主引用文献: Aziz, F.,Reddy, K.,Fernandez Vega, V.,Dey, R.,Hicks, K.A.,Rao, S.,Jordan, L.O.,Smith, E.,Shumate, J.,Scampavia, L.,Carpino, N.,Spicer, T.P.,French, J.B.; Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins.; J.Med.Chem., 67:1949-1960, 2024; PubMed: 38252624; DOI: 10.1021/acs.jmedchem.3c01763

実験手法

X-RAY DIFFRACTION (2.46 Å)