8U4C
Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation.
Summary for 8U4C
Entry DOI | 10.2210/pdb8u4c/pdb |
EMDB information | 41878 |
Descriptor | Insulin receptor, Insulin-like growth factor II (2 entities in total) |
Functional Keywords | insulin receptor, igf2, rtk, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 393718.25 |
Authors | |
Primary citation | An, W.,Hall, C.,Li, J.,Hung, A.,Wu, J.,Park, J.,Wang, L.,Bai, X.C.,Choi, E. Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15:2609-2609, 2024 Cited by PubMed: 38521788DOI: 10.1038/s41467-024-46990-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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