8U0H

Crystal structure of PTPN2 with a PROTAC

Summary for 8U0H

• Entry DOI: 10.2210/pdb8u0h/pdb
• Descriptor: PTPN2, (5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[2-(4-{3-[(3R)-2,6-dioxopiperidin-3-yl]-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl}piperidin-1-yl)acetamido]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid, ACETATE ION, ... (5 entities in total)
• Functional Keywords: protein tyrosine phosphatase, degrader, protac, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 78028.07

Authors

Jain, R.,Longenecker, K.,Qiu, W. (deposition date: 2023-08-29, release date: 2024-09-04)

• Primary citation: Hao, Q.,Rathinaswamy, M.K.,Klinge, K.L.,Bratkowski, M.,Mafi, A.,Baumgartner, C.K.,Hamel, K.M.,Veits, G.K.,Jain, R.,Catalano, C.,Fitzgerald, M.,Hird, A.W.,Park, E.,Vora, H.U.,Henderson, J.A.,Longenecker, K.,Hutchins, C.W.,Qiu, W.,Scapin, G.,Sun, Q.,Stoll, V.S.,Sun, C.,Li, P.,Eaton, D.,Stokoe, D.,Fisher, S.L.,Nasveschuk, C.G.,Paddock, M.,Kort, M.E.; Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex.; Commun Chem, 7:183-183, 2024; PubMed: 39152201; DOI: 10.1038/s42004-024-01263-7

Experimental method

X-RAY DIFFRACTION (1.93 Å)