8U03

Crystal structure of non-glycosylated 10E8-GT10.1 scaffold in complex with a human 10E8 NGS precursor (10E8-NGS-03)

Summary for 8U03

• Entry DOI: 10.2210/pdb8u03/pdb
• Descriptor: 10E8-NGS-03 Fab heavy chain, 10E8-NGS-03 Fab Light Chain, 10E8-GT10.1 epitope scaffold, ... (6 entities in total)
• Functional Keywords: vaccine, broadly neutralizing antibody, hiv, gp41, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 65817.79

Authors

Irimia, A.,Wilson, I.A. (deposition date: 2023-08-28, release date: 2024-06-12, Last modification date: 2024-06-19)

• Primary citation: Schiffner, T.,Phung, I.,Ray, R.,Irimia, A.,Tian, M.,Swanson, O.,Lee, J.H.,Lee, C.D.,Marina-Zarate, E.,Cho, S.Y.,Huang, J.,Ozorowski, G.,Skog, P.D.,Serra, A.M.,Rantalainen, K.,Allen, J.D.,Baboo, S.,Rodriguez, O.L.,Himansu, S.,Zhou, J.,Hurtado, J.,Flynn, C.T.,McKenney, K.,Havenar-Daughton, C.,Saha, S.,Shields, K.,Schulze, S.,Smith, M.L.,Liang, C.H.,Toy, L.,Pecetta, S.,Lin, Y.C.,Willis, J.R.,Sesterhenn, F.,Kulp, D.W.,Hu, X.,Cottrell, C.A.,Zhou, X.,Ruiz, J.,Wang, X.,Nair, U.,Kirsch, K.H.,Cheng, H.L.,Davis, J.,Kalyuzhniy, O.,Liguori, A.,Diedrich, J.K.,Ngo, J.T.,Lewis, V.,Phelps, N.,Tingle, R.D.,Spencer, S.,Georgeson, E.,Adachi, Y.,Kubitz, M.,Eskandarzadeh, S.,Elsliger, M.A.,Amara, R.R.,Landais, E.,Briney, B.,Burton, D.R.,Carnathan, D.G.,Silvestri, G.,Watson, C.T.,Yates 3rd, J.R.,Paulson, J.C.,Crispin, M.,Grigoryan, G.,Ward, A.B.,Sok, D.,Alt, F.W.,Wilson, I.A.,Batista, F.D.,Crotty, S.,Schief, W.R.; Vaccination induces broadly neutralizing antibody precursors to HIV gp41.; Nat.Immunol., 25:1073-1082, 2024; PubMed: 38816615; DOI: 10.1038/s41590-024-01833-w

Experimental method

X-RAY DIFFRACTION (2.72 Å)