8TXV
Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 1)
Summary for 8TXV
Entry DOI | 10.2210/pdb8txv/pdb |
EMDB information | 41706 |
Descriptor | Histone H3.1, Histone H4, Histone H2B type 1-C/E/F/G/I, ... (8 entities in total) |
Functional Keywords | nucleosome core particle, chromatin, rnf168, miu2-lrm domains, dna repair, dna double-strand break, homologous recombination, brca1-bard1, 53bp1, ubiquitin, structural protein-dna-transferase complex, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 12 |
Total formula weight | 275187.91 |
Authors | Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, G.,Mer, G. (deposition date: 2023-08-24, release date: 2024-01-17, Last modification date: 2024-03-20) |
Primary citation | Hu, Q.,Zhao, D.,Cui, G.,Bhandari, J.,Thompson, J.R.,Botuyan, M.V.,Mer, G. Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84:839-853.e12, 2024 Cited by PubMed: 38242129DOI: 10.1016/j.molcel.2023.12.036 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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