8TVN
IRAK4 in complex with compound 23
Summary for 8TVN
Entry DOI | 10.2210/pdb8tvn/pdb |
Related | 8tvm |
Descriptor | Interleukin-1 receptor-associated kinase 4, N-{1-[(1R,2S)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1R,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2H-pyrazolo[3,4-b]pyridine-5-carboxamide (3 entities in total) |
Functional Keywords | kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 140501.72 |
Authors | |
Primary citation | Bolduc, P.N.,Pfaffenbach, M.,Evans, R.,Xin, Z.,Henry, K.L.,Gao, F.,Fang, T.,Silbereis, J.,Vera Rebollar, J.,Li, P.,Chodaparambil, J.V.,Metrick, C.,Peterson, E.A. A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors. Acs Med.Chem.Lett., 15:714-721, 2024 Cited by PubMed: 38746903DOI: 10.1021/acsmedchemlett.4c00102 PDB entries with the same primary citation |
Experimental method |
Structure validation
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