8TTY
Crystal structure of monkey TLR7 ectodomain with compound 5
Summary for 8TTY
Entry DOI | 10.2210/pdb8tty/pdb |
Descriptor | Toll-like receptor 7, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | toll-like receptor 7, immune system |
Biological source | Macaca mulatta (Rhesus monkey) |
Total number of polymer chains | 2 |
Total formula weight | 194093.21 |
Authors | Critton, D.A. (deposition date: 2023-08-15, release date: 2024-02-07, Last modification date: 2024-02-28) |
Primary citation | Poudel, Y.B.,He, L.,Cox, M.,Zhang, Q.,Johnson, W.L.,Cong, Q.,Cheng, H.,Chowdari, N.S.,Tarby, C.,Donnell, A.F.,Broekema, M.,O'Malley, D.P.,Zhang, Y.,A M Subbaiah, M.,Kumar, B.V.,Subramani, L.,Wang, B.,Li, Y.X.,Sivaprakasam, P.,Critton, D.,Mulligan, D.,Sandhu, B.,Xie, C.,Ramakrishnan, R.,Nagar, J.,Dudhgaonkar, S.,Oderinde, M.S.,Murtaza, A.,Schieven, G.L.,Mathur, A.,Gavai, A.V.,Vite, G.,Gangwar, S. Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology. Acs Med.Chem.Lett., 15:181-188, 2024 Cited by PubMed: 38352830DOI: 10.1021/acsmedchemlett.3c00455 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.101 Å) |
Structure validation
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