8TQS

Complex of human thrombin (S195A) bound to a bivalent inhibitor comprised of DNA Aptamer HD22 conjugated to Dabigatran with a linker.

8TQS の概要

• エントリーDOI: 10.2210/pdb8tqs/pdb
• 分子名称: DNA (30-MER), Thrombin heavy chain, Prothrombin, ... (9 entities in total)
• 機能のキーワード: human thrombin, dna aptamer, dabigatran, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44937.87

構造登録者

Krishnaswamy, S.,Kumar, S. (登録日: 2023-08-08, 公開日: 2024-05-01, 最終更新日: 2024-05-22)

• 主引用文献: Yu, H.,Kumar, S.,Frederiksen, J.W.,Kolyadko, V.N.,Pitoc, G.,Layzer, J.,Yan, A.,Rempel, R.,Francis, S.,Krishnaswamy, S.,Sullenger, B.A.; Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors.; Nat Commun, 15:3977-3977, 2024; PubMed: 38730234; DOI: 10.1038/s41467-024-48211-6

実験手法

X-RAY DIFFRACTION (2.207 Å)